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A 2021 review of adulteration studies found undeclared prescription ingredients in weight-loss supplements: 15.3% contained sibutramine, withdrawn from the US market for cardiovascular risk, 13.9% phenolphthalein, pulled over carcinogenicity concerns, and 5.1% fluoxetine
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Developed initially to manage diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists have skyrocketed in popularity since the US Food & Drug Administration first approved semaglutide (brand name Ozempic/Wegovy) for weight loss in 2021
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